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シトシンアナログによる塩基の誤対合と変異 Mutagenic cytosine analogs:Mispairing and mutagenesis

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抄録

We have found two highly mutagenic cytosine analogs, N^4-aminocytidine and P-nucleoside. Inside cells, these analogs are metabolized to the triphosphates, which can be incorporated into DNA by the replication machinery. Due to their ability to pair with guanine and adenine, they can induce replicational errors which would result in mutations. There seems to be two reasons for their high mutagenic potency. First, their efficient incorporation and low tautomeric constants cause high error rates in replication. Second, the analogs are retained in DNA because the cellular repair systems cannot remove these incorporated analogs efficiently.

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各種コード

  • NII論文ID(NAID)
    110001713570
  • NII書誌ID(NCID)
    AN1006217X
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    09100865
  • NDL 記事登録ID
    4597322
  • NDL 雑誌分類
    ZR1(科学技術--生物学)
  • NDL 請求記号
    Z18-1694
  • データ提供元
    CJP書誌  NDL  NII-ELS 
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